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Medchemexpress LLC Gozanertinib | 1226549-49-0 | 98.4% | 10 MG
Supplier: Medchemexpress LLC HY12877810MG
Gozanertinib is an orally active furanopyrimidine-based EGFR inhibitor. It occupies the ATP-binding site and demonstrates significant antitumor efficacy by inhibiting both wild-type EGFR and the L858R/T790M mutant. This compound is for research use only.
- Orally active furanopyrimidine-based EGFR inhibitor
- Occupies the ATP-binding site
- Inhibits EGFRWT with an IC50 of 15 nM
- Inhibits EGFRL858R/T790M with an IC50 of 48 nM
- Demonstrates significant antitumor efficacy
- Interacts via covalent bonding, hydrogen bonds, and hydrophobic interactions
- Shows inhibitory activity against HCC827, H1975, and A431 cell lines
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