Medchemexpress LLC Gozanertinib | 1226549-49-0 | 98.4% | 100 MG

Supplier:  Medchemexpress LLC HY128778100MG

Gozanertinib, also known as DBPR112, is an orally active furanopyrimidine-based EGFR inhibitor. It functions by occupying the ATP-binding site and demonstrates significant antitumor efficacy.

• Inhibits EGFRWT with an IC50 of 15 nM
• Inhibits EGFRL858R/T790M with an IC50 of 48 nM
• Induces dose-dependent reduction of phosphorylated EGFR in H1975 cells
• Demonstrates inhibitory activity against HCC827 (CC50=25 nM), H1975 (CC50=620 nM), and A431 (CC50=1.02 μM) cell lines
• Reduces tumor growth in HCC827 tumor models
• Shows antitumor effect in H1975 tumor models

Catalog No. 50-003-38580