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Cayman Chemical GPR52 Comp-43 50mg
Supplier: Cayman Chemical 3356450 MG
A GPR52 antagonist (IC50 = 0.63 µM); reduces mHTT protein levels in STHdhQ7/Q111 cells in a concentration-dependent manner; reduces apoptosis induced by growth factor deprivation in primary striatal neurons isolated from HdhQ7/Q140 mice; decreases striatal levels of soluble and insoluble mHTT, as well as increases the latency to fall in the rotarod test, in the HdhQ140 mouse model of Huntington's disease at 5 mg/kg
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