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Cayman Chemical GPR52 Comp-43 50mg
Supplier: Cayman Chemical 3356450 MG
A dual inhibitor of EGFR and HER2 (IC50s 22 and 32 nM respectively) selective for EGFR and HER2 over HER4 (IC50 190 nM) and a panel of 21 additional kinases (IC50s 2500 nM for all) inhibits proliferation in a panel of EGFR and/or HER2 signaling-dependent cancer cells (IC50s 0.24-0.94 M) reduces tumor growth in a Sal2 murine salivary gland tumor model as well as GEO colon and KPL4 breast cancer mouse xenograft models in a dose-dependent manner reduces tumor cell motility intravasation and EGF-induced invasion in an MTLn3E metastatic mammary adenocarcinoma mouse xenograft model at 100 mg/kg
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