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Medchemexpress LLC GPX4-IN-3 | 2761004-85-5 | 99.8% | C29H24ClN3O3S | 100 MG
Supplier: Medchemexpress LLC HY141809100MG
GPX4-IN-3 is a potent and selective glutathione peroxidase 4 (GPX4) inhibitor and a selective ferroptosis inducer. It demonstrates significant inhibition of GPX4 and effectively induces ferroptosis in various cell lines, showing a strong ability to increase lipid peroxides. This compound also exhibits antitumor activity and good biological safety in preclinical models, effectively suppressing tumor growth.
- Potent glutathione peroxidase 4 (GPX4) inhibitor
- Selective ferroptosis inducer
- Increases lipid peroxide levels
- Induces ferroptosis with satisfactory selectivity
- Increases reactive oxygen species (ROS) levels in 4T1 cells
- Exhibits antitumor activity
- Good biological safety in vivo
- Suppresses tumor growth in mouse xenograft models
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