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AdipoGen GPx8 human pAb IN103
Supplier: AdipoGen AG25B0028C100
Polyclonal Antibody. Recognizes human GPx8. Source Rabbit. Applications ICC, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. GPxs are glutathione peroxidases involved in balancing the H2O2 homeostasis in signaling cascades. GPxs have been known to catalyze the reduction of H2O2 or organic hydroperoxides to water or the corresponding alcohols, respectively, typically using glutathione GSH as reductant. GPx8 probable glutathione peroxidase 8 is a 209-aa, 24kDa protein with an N-terminal cytosolic tip, a predicted transmembrane segment and a catalytic domain located in the endoplasmic reticulum ER lumen. GPx8 is a CysGPxs with low glutathione peroxidase activity. A recent study identified GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease. GPx8 cleavage by NS3-4A occurs at Cys11, removing the cytosolic tip of GPx8 and was observed in different experimental systems as well as in liver biopsies from patients with chronic hepatitis C.
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