Medchemexpress LLC GRA Ex-25 | 307983-31-9 | 99.1% | C29H36F3N3O5 | 5 MG

Supplier:  Medchemexpress LLC HY506755MG

GRA Ex-25 is an inhibitor of glucagon receptor, with IC50 of 56 and 55 nM for rat and human glucagon receptors, respectively. It binds a human glucagon receptor (h-GlucRbind) with a Ki of 63 nM and shows moderate glucagon-induced adenylate cyclase inhibition (h-GlucRcyclase) with a Ki of 254 nM. It significantly reduces blood glucose caused by exogenous administration of glucagon in a rat model by inhibiting the rise in blood glucose levels elicited by exogenously administered glucagon, most likely due to direct inhibition of glucagon-stimulated hepatic glucose output. Intended for research use only.

• Inhibits glucagon receptor.
• IC50 of 56 nM for rat glucagon receptors.
• IC50 of 55 nM for human glucagon receptors.
• Binds human glucagon receptor with a Ki of 63 nM.
• Shows moderate glucagon-induced adenylate cyclase inhibition with a Ki of 254 nM.
• Significantly reduces blood glucose in a rat model.

Catalog No. 50-003-58163