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Medchemexpress LLC Gracillin | 19083-00-2 | 885.04 | 25 MG
SDP

Catalog No. 5000389864
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Gracillin is a steroidal saponin extracted from plant roots with anti-tumor properties. It can induce cancer cell apoptosis and autophagy.

  • Steroidal saponin.
  • Exhibits anti-tumor properties.
  • Induces cancer cell apoptosis and autophagy.
  • Shows broad-spectrum inhibitory effects on cancer cell viability (e.g., A2780, A549, BXPC-3, Bel-7402, Capan-2, HCT-8, HL-60, HeLa, MCF7, PANC-1, SW1990 cells).
  • Disrupts mitochondrial function by inhibiting ATP production, activating AMPK, and inhibiting oxygen consumption rate (OCR) in H460 and A549 cells.
  • Induces ROS generation in H460, H1299, H226B, and A549 cells.
  • Blocks cell cycle in G1 phase and induces apoptosis and autophagy in A549 cells.
  • Inhibits tumor growth of xenograft tumors in lung (H1299), prostate (DU145), and colorectum (HCT116) cancer cells, as well as patient-derived xenograft colon and lung tumors.

Catalog No. 50-003-89864 Supplier Medchemexpress LLC Supplier No. 25MGHYN0706
May include imposed supplier surcharges.
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Gracillin is a steroidal saponin extracted from plant roots with anti-tumor properties. It can induce cancer cell apoptosis and autophagy.

  • Steroidal saponin.
  • Exhibits anti-tumor properties.
  • Induces cancer cell apoptosis and autophagy.
  • Shows broad-spectrum inhibitory effects on cancer cell viability (e.g., A2780, A549, BXPC-3, Bel-7402, Capan-2, HCT-8, HL-60, HeLa, MCF7, PANC-1, SW1990 cells).
  • Disrupts mitochondrial function by inhibiting ATP production, activating AMPK, and inhibiting oxygen consumption rate (OCR) in H460 and A549 cells.
  • Induces ROS generation in H460, H1299, H226B, and A549 cells.
  • Blocks cell cycle in G1 phase and induces apoptosis and autophagy in A549 cells.
  • Inhibits tumor growth of xenograft tumors in lung (H1299), prostate (DU145), and colorectum (HCT116) cancer cells, as well as patient-derived xenograft colon and lung tumors.

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