Granzyme B Mouse, anti-Human, RB780, Clone: GB11, BD Horizon™

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 568705

Catalog No. BDB568705

Description

The GB11 antibody specifically reacts with human granzyme B, a serine protease of approximately 32 kDa. Granzyme B is stored in the granules of cytotoxic T lymphocytes and NK cells along with the pore-forming protein perforin. In the classic model of target cell lysis, perforins create holes in the target cell membrane allowing entrance of granzymes. Granzyme B has been shown to act on specific substrates including caspase-3, -7, -9, and -10 which in turn give rise to enzymes that mediate apoptosis. Granzyme B may also be involved in the hydrolysis of extracellular matrix components. Detectable levels of granzyme B have been detected in sera from healthy volunteers. The immunogen used to generate the GB11 hybridoma was human granzyme B isolated from an NK cell line.

Specifications

• Antigen: Granzyme B
• Clone: GB11
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide
• Immunogen: Human Granzyme B
• Regulatory Status: RUO
• Gene ID (Entrez): 3002
• Content And Storage: Refrigerate (2°C to 8°C)

• Applications: Flow Cytometry
• Conjugate: RB780
• Host Species: Mouse
• Quantity: 100 Tests
• Primary or Secondary: Secondary
• Target Species: Human
• Isotype: IgG1 κ