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Medchemexpress LLC Grazoprevir potassium salt | 1206524-86-8 | C38H49KN6O9S | 50 MG
Supplier: Medchemexpress LLC HY15298A50MG
Grazoprevir potassium salt is a selective inhibitor of Hepatitis C virus (HCV) NS3/4a protease, demonstrating broad activity across various genotypes and resistant variants. It also inhibits SARS-CoV-2 3CLpro activity. This compound has shown efficacy in vivo against chronic-HCV-infected chimpanzees and good plasma and liver exposure in dogs, highlighting its potential as an antiviral agent.
- Selective inhibitor of Hepatitis C virus NS3/4a protease
- Broad activity across genotypes and resistant variants
- Effective against major genotypes and common resistant mutations
- Inhibits SARS-CoV-2 3CLpro activity
- Demonstrates subnanomolar to low-nanomolar EC50s against genotypes 1a, 1b, and 2a
- Maintains excellent potency against HCV replication mutants
- Shows efficacy against chronic-HCV-infected chimpanzees
- Achieves good plasma and high liver exposure in dogs
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