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Medchemexpress LLC GSK-3β inhibitor 3 | 1448990-73-5 | 99.2% | C18H14FNO2S | 50 MG
Supplier: Medchemexpress LLC HY14148050MG
GSK-3β inhibitor 3 is a potent, selective, irreversible, and covalent inhibitor of Glycogen Synthase Kinase 3β (GSK-3β), with an IC50 of 6.6 μM. It can be used for the research of acute promyelocytic leukemia.
- Potent, selective, irreversible, and covalent inhibitor of Glycogen Synthase Kinase 3β (GSK-3β)
- Has an IC50 of 6.6 μM against GSK-3β
- Used for acute promyelocytic leukemia research
- Inhibits GSK-3α activity by 87.3% (at 100 μM)
- Dose-dependently inhibits the growth of NB4 and NB4-R1 cells
- Increases apoptosis in NB4 and NB4-R1 cells
- Inhibits tumor growth in mice by 75.97% (15 mg/kg/d i.p. for 2 weeks)
- Exhibits long T1/2 of 14.2 h and high AUC values in mice
- Low cytotoxicity on human normal liver cells (LO2) and human umbilical vein endothelial cells (HUVECs)
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