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Apexbio Technology LLC GSK J1 1373422-53-7 200mg
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Catalog No. 5000097279
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GSK J1 (CAS 1373422-53-7) is a selective inhibitor of the histone demethylase JMJD3 which demethylates histone H3 on lysine 27 (H3K27) and is dependent on Fe2 and -ketoglutarate as cofactors GSK J1 inhibits JMJD3 with an IC50 of 60 nM Due to its polar carboxyl group GSK J1 exhibits limited cell permeability to address this ester derivatives have been developed that undergo rapid hydrolysis to release active GSK J1 intracellularly GSK J1 is utilized in studies investigating epigenetic regulation inflammatory responses and macrophage function

Catalog No. 50-000-97279 Supplier Apexbio Technology LLC Supplier No. A4191200
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GSK J1 (CAS 1373422-53-7) is a selective inhibitor of the histone demethylase JMJD3 which demethylates histone H3 on lysine 27 (H3K27) and is dependent on Fe2 and -ketoglutarate as cofactors GSK J1 inhibits JMJD3 with an IC50 of 60 nM Due to its polar carboxyl group GSK J1 exhibits limited cell permeability to address this ester derivatives have been developed that undergo rapid hydrolysis to release active GSK J1 intracellularly GSK J1 is utilized in studies investigating epigenetic regulation inflammatory responses and macrophage function

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