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Active Motif GSK-J1 (cell impermeable)
Supplier: Active Motif 14068
Active Motif's GSK-J1 is a potent and selective inhibitor of Jumonji H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM, human JMJD3). It is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic site of the enzyme. The COOH group confers cell impermeability and, as such, is useful as a standard in vitro assay. A cell permeable ethyl ester analog is also available (Catalog No. 14070).
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