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Apexbio Technology LLC GSK J5 HCl, 5mg CAS# 1394854-51-3 (free base)
Supplier: Apexbio Technology LLC A87925
GSK J5 HCl is the hydrochloride form of GSK J5. GSK J5 is an inactive isomer of GSK J4 and a cell-permeable ester derivative of inactive control GSK J2. Lysine-specific demethylase 6B (KDM6B), also known as Jumonji domain-containing protein D3 (JMJD3), was overexpressed in patients with AML and these patients have a poor prognosis. KDM6B-specific pharmacological inhibitor GSK-J4 had a significant anti-proliferative effect in AML cell lines and freshly isolated BM monocytes (MNCs) from AML patients, while H3K27me3 levels were also increasing. GSK-J4 also caused apoptosis and cell cycle arrest in vitro, and reduced tumor burden in vivo in AML xenograft mouse models. It is worth noting that injection of GSK-J4 attenuated disease progression in a human AML xenograft mouse model. Other sizes are also available. Please inqury us for quote.
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