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Apexbio Technology LLC GSK1016790A 942206-85-1 25mg
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Catalog No. 5000087790
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GSK1016790A (CAS 942206-85-1) is a potent small molecule agonist of the transient receptor potential vanilloid 4 (TRPV4) channel a Ca2 -permeable nonselective cation channel involved in diverse physiological processes including osmoregulation vascular tone skin integrity airway function and nociception GSK1016790A induces Ca2 influx in TRPV4-expressing mouse and human embryonic kidney (HEK) cells with EC50 values of 18 nM and 2 1 nM respectively and elicits dose-dependent activation of TRPV4 whole-cell currents In ex vivo mouse bladder models it triggers contractions and bladder overactivity through TRPV4 activation GSK1016790A is widely used to probe TRPV4-mediated signaling in cellular and physiological studies

Catalog No. 50-000-87790 Supplier Apexbio Technology LLC Supplier No. C506525
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GSK1016790A (CAS 942206-85-1) is a potent small molecule agonist of the transient receptor potential vanilloid 4 (TRPV4) channel a Ca2 -permeable nonselective cation channel involved in diverse physiological processes including osmoregulation vascular tone skin integrity airway function and nociception GSK1016790A induces Ca2 influx in TRPV4-expressing mouse and human embryonic kidney (HEK) cells with EC50 values of 18 nM and 2 1 nM respectively and elicits dose-dependent activation of TRPV4 whole-cell currents In ex vivo mouse bladder models it triggers contractions and bladder overactivity through TRPV4 activation GSK1016790A is widely used to probe TRPV4-mediated signaling in cellular and physiological studies

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