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Apexbio Technology LLC GSK126 1346574-57-9 50mg
SDP

Catalog No. 5000063187
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GSK126 (CAS 1346574-57-9) is a small-molecule inhibitor of EZH2 exhibiting a Ki value of 93 pM EZH2 a catalytic subunit of polycomb repressive complex 2 (PRC2) often exhibits increased expression or activating mutations in various cancers correlating with tumor progression and poorer prognosis GSK126 binds preferentially to activated EZH2/PRC2 complexes and shows enhanced sensitivity toward lymphoma cell lines harboring EZH2 mutations (Y641N Y641F A677G) It demonstrates growth-inhibitory activity in small cell lung cancer (DMS53 LU30 H209) cells and ovarian cancer cells restoring ARNTL expression and increasing cisplatin sensitivity In mouse xenograft tumor models with EZH2-mutant lymphoma intermittent dosing of GSK126 suppresses tumor growth highlighting potential therapeutic relevance in oncology research

Catalog No. 50-000-63187 Supplier Apexbio Technology LLC Supplier No. A344650
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GSK126 (CAS 1346574-57-9) is a small-molecule inhibitor of EZH2 exhibiting a Ki value of 93 pM EZH2 a catalytic subunit of polycomb repressive complex 2 (PRC2) often exhibits increased expression or activating mutations in various cancers correlating with tumor progression and poorer prognosis GSK126 binds preferentially to activated EZH2/PRC2 complexes and shows enhanced sensitivity toward lymphoma cell lines harboring EZH2 mutations (Y641N Y641F A677G) It demonstrates growth-inhibitory activity in small cell lung cancer (DMS53 LU30 H209) cells and ovarian cancer cells restoring ARNTL expression and increasing cisplatin sensitivity In mouse xenograft tumor models with EZH2-mutant lymphoma intermittent dosing of GSK126 suppresses tumor growth highlighting potential therapeutic relevance in oncology research

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