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Medchemexpress LLC GSK143 dihydrochloride | 2341796-81-2 | 99.4% | 1 ML
SDP

Catalog No. 5000340025
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GSK143 dihydrochloride is an orally active, highly selective spleen tyrosine kinase (SYK) inhibitor (pIC50 7.5) that also inhibits phosphorylated Erk (pErk: pIC50 7.1). It reduces inflammation and prevents immune cell recruitment in the intestinal muscularis in mice.

  • Targets spleen tyrosine kinase (SYK) and phosphorylated Erk (pErk).
  • Orally active and highly selective.
  • Reduces inflammation and prevents immune cell recruitment in intestinal muscularis in mice.
  • Inhibits ZAP-70, LCK, LYN, JAK1/2/3, Aurora B, hWB, and hERG with varying pIC50 values.
  • Has an IC50 of 323 nM in chronic lymphocytic leukaemia (CLL) cells.
  • Abrogates SYK phosphorylation and calcium flux in CLL cells.
  • Reduces cytokine expression in bone marrow derived macrophages.
  • Reduces cutaneous reverse passive Arthus reaction in rats.

Catalog No. 50-003-40025 Supplier Medchemexpress LLC Supplier No. HY12736A10MM/1ML
May include imposed supplier surcharges.
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GSK143 dihydrochloride is an orally active, highly selective spleen tyrosine kinase (SYK) inhibitor (pIC50 7.5) that also inhibits phosphorylated Erk (pErk: pIC50 7.1). It reduces inflammation and prevents immune cell recruitment in the intestinal muscularis in mice.

  • Targets spleen tyrosine kinase (SYK) and phosphorylated Erk (pErk).
  • Orally active and highly selective.
  • Reduces inflammation and prevents immune cell recruitment in intestinal muscularis in mice.
  • Inhibits ZAP-70, LCK, LYN, JAK1/2/3, Aurora B, hWB, and hERG with varying pIC50 values.
  • Has an IC50 of 323 nM in chronic lymphocytic leukaemia (CLL) cells.
  • Abrogates SYK phosphorylation and calcium flux in CLL cells.
  • Reduces cytokine expression in bone marrow derived macrophages.
  • Reduces cutaneous reverse passive Arthus reaction in rats.

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