Medchemexpress LLC GSK1702934A | 924377-85-5 | 99.11% | 395.52 | 10 MG

Supplier:  Medchemexpress LLC HY11109850MG

GSK1702934A is a selective agonist for TRPC3, a transient receptor potential canonical channel. It plays a role in modulating cardiac contractility and arrhythmogenesis through the activation of TRPC3. In vitro studies have shown its ability to induce TRPC3/6-currents in HEK293 cells, with EC50 values of 0.08 mM for TRPC3 and 0.44 mM for TRPC6. It also induces transient, non-selective conductance and prolonged action potentials in TRPC3-overexpressing myocytes, and promotes NCX currents. In vivo, GSK1702934A has been observed to transiently increase blood pressure in conscious Sprague Dawley rats at doses ranging from 0.3-3 mg/kg.

• Acts as a selective agonist for TRPC3.
• Modulates cardiac contractility and arrhythmogenesis by activating TRPC3.
• Induces TRPC3/6-currents in HEK293 cells.
• Promotes NCX currents in TRPC3-overexpressing myocytes.
• Increases blood pressure in vivo in animal models.

Catalog No. 50-003-43306