Apexbio Technology LLC GSK1904529A 1089283-49-7 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC A13025.1

GSK1904529A (CAS 1089283-49-7) is a small-molecule inhibitor targeting insulin-like growth factor-I receptor (IGF-1R) Mechanistically it acts as a reversible ATP-competitive antagonist inhibiting IGF-1R kinase activity with an IC50 of approximately 27 nM and a Ki value of 1 6 nM In NIH-3T3/LISN cells it reduces IGF-1R phosphorylation at an IC50 of about 22 nM subsequently attenuating phosphorylation of downstream effectors such as AKT IRS-1 and ERK pathways GSK1904529A also suppresses proliferation in various tumor cell lines through cell-cycle arrest at the G1 phase and demonstrates tumor growth inhibition in xenograft mouse models It serves as a research tool for investigating IGF-1R signaling in oncology

Catalog No. 50-000-63819