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Apexbio Technology LLC GSK2126458(Synonyms: Omipalisib, GSK-2126458, GSK 2126458, Omipalisib (GSK2126458)), 10mM (in 1mL DMSO), CAS: 1086062-66-9.
Supplier: Apexbio Technology LLC A85565.1
GSK2126458 (CAS 1086062-66-9) is a small molecule inhibitor targeting PI3K and mTOR pivotal regulators in cell growth proliferation and tumor progression GSK2126458 demonstrates potent inhibitory activity against PI3K (Ki 19 pM) In colon cancer cells combined use with DDR1-IN-1 enhances its antiproliferative effects Additionally the compound induces G1 phase arrest in BT474 breast cancer cells and sensitizes nasopharyngeal carcinoma (NPC) cell lines to radiation therapy In vivo studies show that combining GSK2126458 with radiation or with MEK and BRAF inhibitors suppresses tumor growth GSK2126458 also influences cellular autophagy pathways highlighting its utility in oncology-focused biomedical research
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