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Apexbio Technology LLC GSK2334470 1227911-45-6 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B21745.1
GSK2334470 (CAS 1227911-45-6) is a highly selective inhibitor of 3-phosphoinositide-dependent protein kinase-1 (PDK1) demonstrating an IC50 of approximately 10 nM It specifically blocks PDK1-mediated phosphorylation of substrate proteins including Akt1 S6K1 and SGK isoforms inhibiting their T-loop phosphorylation sites GSK2334470 does not significantly inhibit other tested protein or lipid kinases This compound facilitates mechanistic research into signaling pathways regulated by PDK1 particularly those involving Akt and downstream effectors in cellular contexts
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