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Selleck Chemical LLC GSK2606414 5mg 1337531-36-8
Supplier: Selleck Chemical LLC S73075MG
GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed. GSK2606414 impairs GANT-61 induced autophagy in NB cells with MYCN amplification. GSK2606414 exacerbates ER stress-induced apoptosis in HCT116 cells while reduces the apoptosis in SIL1 KD HeLa cells. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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