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Medchemexpress LLC GSK4112 | 1216744-19-2 | 99.9% | C18H21ClN2O4S | 1 ML
SDP

Catalog No. 5000354499
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GSK4112 is a Rev-erbα agonist, with an EC50 of 0.4 μM, used as a chemical tool to study Rev-erbα's role in transcriptional repression, circadian biology, and metabolic pathways. It represses bmal1 and gluconeogenesis-related gene expression in vitro, recruits HDAC3, and modulates hepatic gene expression. In vivo, it mitigates Fas-induced acute hepatic damage.

  • Rev-erbα agonist (EC50 0.4 μM)
  • Chemical tool for studying transcriptional repression, circadian biology, and metabolic pathways
  • Represses bmal1 and gluconeogenesis-related gene expression
  • Recruits HDAC3 and modulates hepatic gene expression
  • Reduces glucose output in murine hepatocytes
  • Mitigates Fas-induced acute hepatic damage in vivo

Catalog No. 50-003-54499 Supplier Medchemexpress LLC Supplier No. HY1441410MM/1ML
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GSK4112 is a Rev-erbα agonist, with an EC50 of 0.4 μM, used as a chemical tool to study Rev-erbα's role in transcriptional repression, circadian biology, and metabolic pathways. It represses bmal1 and gluconeogenesis-related gene expression in vitro, recruits HDAC3, and modulates hepatic gene expression. In vivo, it mitigates Fas-induced acute hepatic damage.

  • Rev-erbα agonist (EC50 0.4 μM)
  • Chemical tool for studying transcriptional repression, circadian biology, and metabolic pathways
  • Represses bmal1 and gluconeogenesis-related gene expression
  • Recruits HDAC3 and modulates hepatic gene expression
  • Reduces glucose output in murine hepatocytes
  • Mitigates Fas-induced acute hepatic damage in vivo

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