Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC GSK4112 (SR6452) | 1216744-19-2 | 99.9% | C18H21ClN2O4S | 100 MG
Supplier: Medchemexpress LLC HY14414100MG
GSK4112, also known as SR6452, is identified as a Rev-erbα agonist with an EC50 value of 0.4 μM. It serves as a valuable chemical tool for investigating the role of Rev-erbα in various biological processes, including transcriptional repression, the regulation of circadian rhythms, and metabolic pathways.
- Interacts with Rev-erbα with an EC50 of 0.4 μM.
- Represses the expression of bmal1 and target genes associated with gluconeogenesis, recruits HDAC3, and modulates Rev-erbα's effect on hepatic gene expression oscillation.
- Reduces glucose output in murine hepatocytes.
- Attenuates Fas-induced hepatic damage in male C57BL/6 mice.
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?