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Apexbio Technology LLC GSK461364 929095-18-1 10mM (in 1mL Ethanol)
Supplier: Apexbio Technology LLC A84415.1
GSK461364 (CAS 929095-18-1) is a reversible ATP-competitive inhibitor that selectively targets Polo-like kinase 1 (Plk1) a serine/threonine kinase crucial in regulating DNA damage responses and cell cycle progression Compared to Plk2 Plk3 and a wider kinase set GSK461364 displays high selectivity for Plk1 In vitro it demonstrates significant anti-proliferative effects across diverse tumor cell lines In vivo research employing xenograft models indicates tumor growth suppression or regression characterized by defects in spindle formation and mitotic arrest Clinically GSK461364 has been investigated via intravenous administration for advanced solid tumors
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