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Medchemexpress LLC GSK8612 | 2361659-62-1 | 99.6% | 520.33 | 1 MG
SDP

Catalog No. 5000438975
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GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1. It inhibits toll-like receptor (TLR)3-induced IRF3 phosphorylation in Ramos cells and type I IFN secretion in primary human mononuclear cells. In THP1 cells, GSK8612 inhibits secretion of IFNβ in response to dsDNA and cGAMP, the natural ligand for STING.

  • Highly selective and potent TBK1 inhibitor
  • Inhibits TLR3-induced IRF3 phosphorylation
  • Inhibits type I IFN secretion in primary human mononuclear cells
  • Inhibits secretion of IFNβ in response to dsDNA and cGAMP in THP1 cells

Catalog No. 50-004-38975 Supplier Medchemexpress LLC Supplier No. HY1119411MG
May include imposed supplier surcharges.
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GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1. It inhibits toll-like receptor (TLR)3-induced IRF3 phosphorylation in Ramos cells and type I IFN secretion in primary human mononuclear cells. In THP1 cells, GSK8612 inhibits secretion of IFNβ in response to dsDNA and cGAMP, the natural ligand for STING.

  • Highly selective and potent TBK1 inhibitor
  • Inhibits TLR3-induced IRF3 phosphorylation
  • Inhibits type I IFN secretion in primary human mononuclear cells
  • Inhibits secretion of IFNβ in response to dsDNA and cGAMP in THP1 cells

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