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Medchemexpress LLC GSK8612 | 2361659-62-1 | 99.6% | 520.33 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY111941100MG

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GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1. It is intended for research use only and not for sale to patients. In vitro, GSK8612 inhibits toll-like receptor (TLR)3-induced IRF3 phosphorylation in Ramos cells and type I IFN secretion in primary human mononuclear cells. In THP1 cells, it inhibits the secretion of IFNβ in response to dsDNA and cGAMP, the natural ligand for STING.

  • Highly selective and potent tank-binding kinase-1 (TBK1) inhibitor.
  • pIC50 of 6.8 for recombinant TBK1.
  • Inhibits TLR3-induced IRF3 phosphorylation in Ramos cells.
  • Inhibits type I IFN secretion in primary human mononuclear cells.
  • Inhibits secretion of IFNβ in response to dsDNA and cGAMP in THP1 cells.

Catalog No. 50-004-38962


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