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Medchemexpress LLC GsMTx4 | 1209500-46-8 | 99.9% | 4095.84 | 500 UG
Supplier: Medchemexpress LLC HYP1410C500UG
GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. It also blocks cation-selective stretch-activated channels (SACs), and attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 serves as a pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology.
- Selectively inhibits cationic-permeable mechanosensitive channels
- Blocks cation-selective stretch-activated channels
- Attenuates lysophosphatidylcholine-induced astrocyte toxicity and microglial reactivity
- Neuroprotective and inhibits demyelination
- Reduces mechanical allodynia induced by inflammation and sciatic nerve injury
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