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Medchemexpress LLC GSTO1-IN-1 | 568544-03-6 | 99.1% | 311.18 | 1 MG
Supplier: Medchemexpress LLC HY11153010MG
GSTO1-IN-1 is a potent inhibitor of glutathione S-transferase omega 1 (GSTO1) with an IC50 of 31 nM. It is intended for research use only. In cellular studies, it inhibits GSTO1 enzyme activity, decreases HCT116 cell viability dose-dependently, and inhibits clonogenic survival at sub-micromolar concentrations. In in vivo studies, it significantly inhibited tumor growth in a human colon cancer cell line xenograft model in nude mice without overt signs of toxicity or significant variations in average body weights over a 5-week treatment period.
- Potent GSTO1 inhibitor with an IC50 of 31 nM.
- Inhibits GSTO1 enzyme activity.
- Decreases HCT116 cell viability.
- Inhibits clonogenic survival.
- Significantly inhibits tumor growth in xenograft models.
- Well tolerated in in vivo studies.
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