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Medchemexpress LLC Gt-653 | 3057627-63-8 | 99.8% | 653.60 | C32H27N7O9 | 10 MG
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Supplier:  Medchemexpress LLC HY15843210MG

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GT-653 is a PROTAC degrader that targets lysine-specific demethylase 5B (KDM5B), promoting ubiquitin-proteasome-dependent degradation and modulating H3K4 methylation in cellular models. It is supplied as a white to off-white solid for research use in biochemical and cellular studies of epigenetic regulation.

  • PROTAC mechanism targeting KDM5B, a histone demethylase.
  • Demonstrated 68.35% degradation of KDM5B at 10 μM in cell assays.
  • Upregulates H3K4me3 levels and activates type-I interferon signaling in prostate cancer cells.
  • Available as a white to off-white powder suitable for in vitro studies.
  • Molecular formula C32H27N7O9; molecular weight 653.60.

Catalog No. 50-002-88318


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