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Apexbio Technology LLC Guanfacine hydrochloride 29110-48-3 10mg
Supplier: Apexbio Technology LLC A345110
Guanfacine hydrochloride (CAS 29110-48-3) is a selective agonist of the 2A-adrenergic receptor displaying approximately 60-fold selectivity over the 2B subtype (Kd 31 nM for 2A) Experimental studies indicate that low doses improve attention in NK1R knockout mice without affecting wild-type animals while higher doses suppress impulsivity in both genotypes In alcohol consumption models guanfacine reduces alcohol intake and attenuates alcohol deprivation effects in rats Additionally guanfacine modulates spinal nociceptive transmission through interactions with delta opioid receptors enhancing analgesic responses in nerve injury models These properties underscore its utility in studies of CNS function addiction and nociception
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