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Medchemexpress LLC Guanidine hydrochloride | 50-01-1 | 98.0% | 25 G
Supplier: Medchemexpress LLC 25GHYB0178A
Guanidine hydrochloride is a strong chaotrope and denaturant of proteins, widely used in biochemical research. It causes co-operative unfolding of the molten globule state at high concentrations and can refold acid-unfolded proteins at low concentrations.
- Induces co-operative unfolding of the molten globule state at concentrations greater than 1 M.
- Refolds acid-unfolded apomyoglobin and cytochrome c at low concentrations.
- Stabilizes the molten globule state.
- Does not affect disulfide bonds.
- Can cause efficient loss of the [PSI+] element from yeast cells at millimolar concentrations.
- Reduces Hsp104-mediated basal and acquired thermotolerance.
- Reduces Hsp104's ability to restore activity of thermally denatured luciferase.
- In vivo, significantly reduces the death rate of infant mice infected with coxsackievirus A16.
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