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Medchemexpress LLC Guanosine 5'-diphosphate sodium | 43139-22-6 | 99.9% | 465.18 | 500 MG
Supplier: Medchemexpress LLC HY113066C500MG
Guanosine 5'-diphosphate sodium is a nucleoside diphosphate known for activating adenosine 5'-triphosphate-sensitive K+ channels. It acts as an iron mobilizer by forming a complex with hepcidin, which inhibits the hepcidin-ferroportin (FPN) interaction and modulates the IL-6/Stat-3 pathway. This compound has been shown to ameliorate Turpentine-induced anemia of inflammation (AI) in mice, especially when combined with FeSO4, highlighting its utility in AI research.
- Activates ATP-sensitive K+ channels.
- Mobilizes iron by inhibiting hepcidin-FPN interaction.
- Modulates IL-6/Stat-3 pathway.
- Ameliorates anemia of inflammation (AI).
- Increases iron absorption and FPN levels in liver, spleen, and enterocytes.
- Reduces iron storage ferritin and Stat-3 phosphorylation.
- Decreases Hamp mRNA and hepcidin expression.
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