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Medchemexpress LLC Guanosine, cyclic 3',5'-(hydrogen phosphate) (TBAOH) | 99.1% | 604.68 | 10 MG
SDP

Supplier:  Medchemexpress LLC HY113469B10MG

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Cyclic GMP (cGMP) TBAOH is an important second messenger and a major intracellular mediator of extracellular signals like nitric oxide (NO) and natriuretic peptides (NPs). Its effects are mediated through cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses.

  • Important second messenger
  • Intracellular mediator of extracellular signals (nitric oxide and natriuretic peptides)
  • Inhibits both platelet adhesion and aggregation
  • Can activate cGMP-mediated protein kinases
  • Can activate cGMP-stimulated phosphodiesterases when acting synergistically with Isoprenaline, reversing cAMP-mediated enhancement or inhibiting cAMP-induced inward calcium current (ICa)

Catalog No. 50-004-36571


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