STEMCELL Technologies Gö6983, Size: 1 mg

Supplier:  STEMCELL Technologies 72462

Gö6983 inhibits several isoforms of protein kinase C (PKC; IC₅₀ = 7, 7, 6, 10, 60, and 20,000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ, and PKCμ, respectively) (Gschwendt et al.).REPROGRAMMING· Enhances reprogramming of mouse embryonic fibroblasts to induced pluripotent stem cells (Dutta et al.).· Direct lineage reprogramming of fibroblasts to mature neurons, in combination with CHIR99021, RepSox, Forskolin, SP600125, Valproic Acid, and Y-27632 (Hu et al.).MAINTENANCE AND SELF-RENEWAL· Inhibits differentiation and maintains pluripotency in mouse embryonic stem cells (Dutta et al.).· Enhances human ground state pluripotent stem cell viability and growth (Gafni et al.).· Inhibits proliferation of human primary fetal bone cells (Krattinger et al.).· Inhibits the formation of protoplatelets from megakaryocytes derived from adult mouse bone marrow (Williams et al.).

Catalog No. 50-197-5925