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Medchemexpress LLC GW 4064 | 278779-30-9 | 99.8% | 542.84 | 200 MG
Supplier: Medchemexpress LLC 200MGHY50108
GW 4064 is a potent Farnesoid X Receptor (FXR) agonist with an EC50 of 65 nM.
- Reduces lipid accumulation in cells and represses oleic acid-induced CD36 protein levels, potentially preventing hepatic lipid accumulation.
- Suppresses weight gain and significantly represses diet-induced hepatic steatosis by lowering triglyceride and free fatty acid levels in the liver.
- Markedly reduces lipid transporter CD36 expression without affecting genes directly involved in lipogenesis.
- Attenuates hepatic inflammation.
- Leads to statistically significant reductions in serum activities of ALT, AST, LDH, and ALP, as well as reduced serum bile acid levels, suggesting hepatoprotective benefits.
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