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Apexbio Technology LLC GW 583340 dihydrochloride 10mg
Supplier: Apexbio Technology LLC B698910
GW 583340 dihydrochloride (CAS 1173023-85-2) is a small molecule inhibitor targeting the tyrosine kinase activity of both EGFR and ErbB2 exhibiting potent inhibitory effects with IC50 values of 0 01 M and 0 014 M respectively In addition to suppressing these receptor-mediated signaling pathways GW 583340 dihydrochloride has been shown to inhibit ABC transporters including ABCG2 and ABCB1 thereby reversing transporter-associated multidrug resistance This compound is utilized in tumor biology research to investigate the modulation of oncogenic signaling mechanisms underlying drug resistance and to explore potential therapeutic strategies
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