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AdipoGen GW311616A . hydrochloride,Chemical. CAS: 197890-44-1
Supplier: AdipoGen AGCR13632M001
GW311616A . hydrochloride, AdipoGen Life Sciences. Chemical. CAS: 197890-44-1. Formula: C19H31N3O4S . HCl. MW: 397.5 . 36.5. Potent, selective intracellular neutrophil elastase (NE, alpha-1-proteinase) inhibitor (by covalently binding to NE). Inhibits human neutrophil elastase (HNE) and is selective over other human serine proteases with IC50 values of 22nM for HNE, >100¿M for trypsin, cathepsin G and plasmin, >3¿M for chymotrypsin and tissue plasminogen activator. Specific beta-cell proliferation promoter. Similar to SerpinB1, which functions through its inhibiting activity of several proteases including neutrophil elastase, cathepsin G and proteinase-3. Reverses insulin resistance and body weight gain in HFD-fed mice, suggesting that the SerpinA1-NE system regulates AMPK signaling, fatty acid oxidation (FAO) and energy expenditure. 197890-44-1
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