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Medchemexpress LLC GW405833 hydrochloride | 1202865-22-2 | 99.59% | 483.82 | 1 ML
Supplier: Medchemexpress LLC HY110036A50MG
GW405833 (L768242) hydrochloride is a potent, selective cannabinoid receptor 2 (CB2) agonist. It has EC50 and Ki values of 0.65 nM and 3.92 nM for CB2, and EC50 and Ki values of 16.1 μM and 4772 nM for CB1. It also acts as a non-competitive CB1 antagonist, exerting its analgesic effect through a CB1 receptor dependent mechanism. It can significantly inhibit the production of cAMP stimulated by Forskolin and inhibits glycolysis by down-regulating HIF-1α, thereby alleviating acute liver failure (ALF).
- Potent, selective cannabinoid receptor 2 (CB2) agonist
- EC50 and Ki values for CB2: 0.65 nM and 3.92 nM respectively
- EC50 and Ki values for CB1: 16.1 μM and 4772 nM respectively
- Non-competitive CB1 antagonist
- Inhibits cAMP production stimulated by Forskolin
- Inhibits glycolysis by down-regulating HIF-1α
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