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Medchemexpress LLC GW405833 hydrochloride | 1202865-22-2 | 99.6% | 483.82 | 25 MG
Supplier: Medchemexpress LLC 25MGHY110036A
GW405833 (L768242) hydrochloride is a potent, selective cannabinoid receptor 2 (CB2) agonist with EC50 and Ki values of 0.65 nM and 3.92 nM for CB2, and 16.1 μM and 4772 nM for CB1. It also acts as a non-competitive CB1 antagonist, achieving its analgesic effect through a CB1 receptor-dependent mechanism. It significantly inhibits the production of cAMP stimulated by Forskolin and inhibits glycolysis by down-regulating HIF-1α, thereby alleviating acute liver failure (ALF). This compound exhibits low-efficacy agonism in spleen membranes and reverse agonist effects in hCB2-CHO cells. It inhibits proliferation of hepatic macrophages, reduces TNF-α and IL-1β expressions, and protects against cell death in ALF models.
- Potent and selective CB2 agonist
- Non-competitive CB1 antagonist
- Inhibits cAMP production
- Alleviates acute liver failure by down-regulating HIF-1α
- Reduces TNF-α and IL-1β expressions
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