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Apexbio Technology LLC GW441756 504433-23-2 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC B22975.1

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GW441756 (CAS 504433-23-2) is a small-molecule inhibitor targeting TrkA kinase and LRRK2 It inhibits TrkA kinase activity with an IC50 of 320 nM potentially modulating downstream signaling involved in cellular proliferation differentiation and apoptosis Selectivity studies indicated limited inhibitory effects on other kinases such as cRaf1 and CDK2 with respective IC50 values above 12 M and 7 M GW441756 induced dose-dependent anti-proliferative and pro-apoptotic effects in the human sarcoma cell line HTB114 It also inhibited LRRK2-mediated phosphorylation at Ser935 (IC50 2 2 M) without significant cytotoxicity (IC50 20 M) GW441756 serves as a research tool in oncology and neurobiology

Catalog No. 50-000-61573


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