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Medchemexpress LLC Gw4869 | 6823-69-4 | 98.9% | 577.50 | 250 MG
Supplier: Medchemexpress LLC 250MGHY19363
GW4869 is a noncompetitive neutral sphingomyelinase (N-SMase) inhibitor with an IC50 of 1 μM. It also acts as an inhibitor of exosome biogenesis and release. This product is intended for research use only.
- Noncompetitive neutral sphingomyelinase (N-SMase) inhibitor
- Inhibits exosome biogenesis and release
- Partially inhibits TNF-induced sphingomyelin (SM) hydrolysis
- Protects from cell death in a dose-dependent manner
- Reduces pro-inflammatory cytokine production in macrophages
- Blocks ceramide-mediated inward budding of multivesicular bodies (MVBs)
- In vivo, inhibits exosome release and mitigates LPS-caused myocardial dysfunction
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