Apexbio Technology LLC GW5074 220904-83-6 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC B14055.1

GW5074 (CAS 220904-83-6) is a synthetic small molecule inhibitor targeting c-Raf kinase with an IC50 of approximately 9 nM GW5074 displays selectivity for c-Raf showing little or no inhibitory activity against various other kinases including cdk1 cdk2 c-src p38 MAP kinase VEGFR2 c-fms and JNK In neuronal cells GW5074 decreases phosphorylation at serine 259 of c-Raf resulting in c-Raf activation At concentrations below 1 M GW5074 confers neuroprotection by sustaining Akt phosphorylation preventing GSK3 activation and thus reducing apoptosis In vivo GW5074 mitigates neurodegeneration in a 3-nitropropionic acid-induced Huntington s disease model demonstrating promise for neurodegenerative research applications

Catalog No. 50-000-62113