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Medchemexpress LLC GW604714X | 853953-65-8 | 98.49% | 471.46 | 50 MG
Supplier: Medchemexpress LLC HY13855950MG
GW604714X is a potent inhibitor of mitochondrial respiration that is supported by pyruvate, but not by other substrates. It acts as a highly specific mitochondrial pyruvate carrier (MPC) inhibitor with a Ki value of less than 0.1 nM. While GW604714X also inhibits L-lactate transport by the plasma membrane monocarboxylate transporter (MCT1), it does so at concentrations more than four orders of magnitude greater than those required for MPC inhibition.
- Potent inhibitor of mitochondrial respiration supported by pyruvate.
- Highly specific mitochondrial pyruvate carrier (MPC) inhibitor with a Ki <0.1 nM.
- Inhibits L-lactate transport by the plasma membrane monocarboxylate transporter (MCT1) at significantly higher concentrations than MPC.
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