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Medchemexpress LLC GW806742X (hydrochloride) | 98.3% | 610.01 | 10 MM * 1 ML
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Supplier:  Medchemexpress LLC HY112292A10MM/1ML

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GW806742X hydrochloride is an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor. It binds the MLKL pseudokinase domain with a Kd of 9.3 μM and has activity against VEGFR2 (IC50=2 nM). This compound retards MLKL membrane translocation and inhibits necroptosis. It is for research use only.

  • ATP mimetic
  • Potent MLKL inhibitor
  • Binds MLKL pseudokinase domain
  • Activity against VEGFR2
  • Retards MLKL membrane translocation
  • Inhibits necroptosis
  • Inhibits necroptotic death of wild-type mouse dermal fibroblasts (MDFs) in a dose-dependent manner
  • Shows inhibition of VEGF induced proliferation of HUVECs with an IC50 of 5 nM

Catalog No. 50-004-38182


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