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Medchemexpress LLC GW806742X hydrochloride | 98.3% | 610.01 | 100 MG
Supplier: Medchemexpress LLC HY112292A100MG
GW806742X hydrochloride is an ATP mimetic and a potent inhibitor of MLKL (Mixed Lineage Kinase Domain-Like protein), binding to the MLKL pseudokinase domain with a Kd of 9.3 μM. It also exhibits activity against VEGFR2 with an IC50 of 2 nM. This compound has been shown to retard MLKL membrane translocation and inhibit necroptosis.
- Retards MLKL membrane translocation
- Inhibits necroptosis
- Inhibits necroptotic death of wild-type mouse dermal fibroblasts (MDFs) stimulated with TSQ in a dose-dependent manner
- Inhibits VEGF-induced proliferation of HUVECs with an IC50 of 5 nM
- Binds MLKL pseudokinase domain with a Kd of 9.3 μM
- Activity against VEGFR2 with an IC50 of 2 nM
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