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Apexbio Technology LLC GW9662(Synonyms: GW-9662, GW 9662, 2-Chloro-5-nitro-N-phenylbenzamide, PPAR gamma antagonist GW9662), 10mM (in 1mL DMSO), CAS: 22978-25-2.
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Supplier:  Apexbio Technology LLC A43005.1

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GW9662 (CAS 22978-25-2) is an antagonist of peroxisome proliferator-activated receptor gamma (PPAR ) a nuclear receptor involved in various biological processes including tumor growth and inflammation GW9662 irreversibly blocks PPAR activity by covalently modifying cysteine residues at its ligand-binding site (IC50 3 3 M) In cellular assays GW9662 inhibits proliferation of breast cancer cell lines (MCF7 MDA-MB-231 MDA-MB-468 IC50 20 30 M) Additionally GW9662 reverses the protective impact of lipopolysaccharide on kidney ischemia/reperfusion injury demonstrating its utility for studying PPAR -mediated pathways in oncology and inflammation models

Catalog No. 50-000-60783


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