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Cayman Chemical GYKI 52466hydrochlorIde 50mg
Supplier: Cayman Chemical 3441850 MG
An allosteric AMPA receptor antagonist; selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also inhibits kainate-induced inward currents in the same cells (IC50 = 11 µM); reduces the amplitude of spontaneous EPSCs in the same cells at 10 µM; increases the latency to seizure onset and reduces mortality in a rat model of 4-AP-induced generalized tonic-clonic seizures at 25 and 50 mg/kg; prevents neuronal damage in the CA1 region of the hippocampus in a four-vessel occlusion-induced rat model of global ischemia-reperfusion injury at 30 mg/kg
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