Cayman Chemical GypenosIde XVII 5mg

Supplier:  Cayman Chemical 345145 MG

A saponin with diverse biological activities; induces autophagic clearance of APP, Aβ40, and Aβ42 in PC12 cells expressing APP695 Swe at 10 µM; prevents the formation of hippocampal and cortical Aβ plaques and ameliorates spatial cognitive deficits in the transgenic APP/PS1 mouse model of Alzheimer's disease at 40 mg/kg; decreases lipid deposition in the aortic sinus and serum levels of MDA, reduces aortic plaque area, and increases serum levels of SOD, GPX, and catalase in ApoE-/- mice; reduces spinal cord edema and neuronal apoptosis in a mouse model of mechanical compression-induced spinal cord injury at 10 and 50 mg/kg; maintains retinal permeability and structure and reduces retinal levels of apoptotic proteins in a db/db mouse model of EArly diabetic retinopathy

Catalog No. 50-294-8111