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Medchemexpress LLC H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Pro-Ile-Leu-Thr-Arg-Ile-Thr-Leu-Glu-OH | 99.32% | 2617.13 | 10 MG
SDP

Catalog No. 5000426262
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ReACp53 is a potent activator of p53, a critical tumor suppressor. It inhibits p53 amyloid formation and restores its function in cancer cells. It penetrates high-grade serous ovarian cancer (HGSOC) cells, converting mutant p53 into a soluble, wild-type-like form. ReACp53 induces cancer cell death, cell cycle arrest, and promotes p53 degradation, specifically targeting cancer cells with mutant p53 while sparing wild-type cells. This makes ReACp53 a promising therapeutic agent for p53-driven cancers.

  • Inhibits p53 amyloid formation.
  • Rescues p53 function in cancer cell lines.
  • Converts mutant p53 to soluble WT-like p53 in HGSOC cells.
  • Induces cancer cell death and cell cycle arrest.
  • Promotes p53 degradation.
  • Targets mutant p53 cancer cells, sparing wild type.
  • Reduces tumor proliferation in animal models.
  • Increases p21 and MDM2 transcription in OVCAR3 xenografts.

Catalog No. 50-004-26262 Supplier Medchemexpress LLC Supplier No. HYP012110MG
May include imposed supplier surcharges.
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ReACp53 is a potent activator of p53, a critical tumor suppressor. It inhibits p53 amyloid formation and restores its function in cancer cells. It penetrates high-grade serous ovarian cancer (HGSOC) cells, converting mutant p53 into a soluble, wild-type-like form. ReACp53 induces cancer cell death, cell cycle arrest, and promotes p53 degradation, specifically targeting cancer cells with mutant p53 while sparing wild-type cells. This makes ReACp53 a promising therapeutic agent for p53-driven cancers.

  • Inhibits p53 amyloid formation.
  • Rescues p53 function in cancer cell lines.
  • Converts mutant p53 to soluble WT-like p53 in HGSOC cells.
  • Induces cancer cell death and cell cycle arrest.
  • Promotes p53 degradation.
  • Targets mutant p53 cancer cells, sparing wild type.
  • Reduces tumor proliferation in animal models.
  • Increases p21 and MDM2 transcription in OVCAR3 xenografts.

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