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Bachem H-Phe-Arg-bNA · 2 HCl
Supplier: Bachem 4000885.1000
H-Phe-Arg-bNA · 2 HCl, 100929-99-5, C25H30N6O2 · 2 HCl, Mr 519.47, 1g. MC-207110, PAbN. Substrate for dipeptidyl aminopeptidase I (cathepsin C). A broad-spectrum efflux pump inhibitor in gram-negative bacteria. PAbN has been evaluated as an adjunct to antibiotics, as efflux in bacteria mediates antibiotic resistance. Vecchione et al. demonstrated that Phe-Arg-b-naphthylamide could potentiate drug activity also against a gram-positive bacterium. PAbN permeabilizes the outer membrane of gram-negative bacteria (Lamers et al.).
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